曹鹏秀，博士

港澳宝80801“精英计划”引进人才

河北省第八批“百人计划”特聘专家

河北省政府特殊津贴专家

联系电话：0311-80787586

电子邮件：[email protected]

所属专业、方向：生理学专业、动物细胞信号转导方向

主要学习和工作经历

1998-2002 于港澳宝80801获得生物教育专业理学学士学位  

2002-2007 于中国科学院遗传与发育生物学研究所获得遗传学专业理学博士学位

2008-2017 在美国Case Western Reserve University、ClevelandClinic和University of Michigan等高校或研究所进行生物医学领域的博士后研究

2018-今     为港澳宝80801生理学专业动物细胞信号转导方向教师

主要教学科研工作

教学: 担任国家级精品资源共享课《组织学与解剖学》主讲教师。主讲课程：《组织学与解剖学》、《组织学与解剖学实验》和《生物信息学》。

研究方向：(1) 肺纤维化进程分子机制研究和有效治疗策略的开发及药物筛选；(2) 雾霾引起肺部重塑的机制研究和干预策略；(3) 吸烟致肺部疾病机制研究及分子治疗策略。

所获荣誉

2019年 荣获第八届河北省高等教育教学成果奖二等奖（第二完成人）

2018-2019年度 港澳宝80801本科毕业论文优秀指导教师

承担的科研项目

国家自然科学青年基金，31900817，2020.1—2022.12，主持人。

国家自然科学面上基金，32071119，2021.1—2024.12，主持人。

河北省人社厅“百人计划”高层次人才支持项目，E2018050011，2019.2—2021.12，主持人。

港澳宝80801科研启动基金，2018.1-2020.12，主持人。

代表性研究论文

1. Cao Pengxiu*, Aoki Yoshiro*, Badri Linda,Walker Natalie M., Manning Casey M., Lagstein Amir, Fearon Eric R., Lama VibhaN. (2017) Autocrine lysophosphatidic acid signaling activates β-catenin andpromotes lung allograft fibrosis. Journal of Clinical Investigation,127(4):1517-1530. *Contributed equally.

2. Ge Wang*,Pengxiu Cao*,Yumei Fan*,Ke Tan.(2020)Emerging roles of HSF1 in cancer: Cellular and molecular episodes. BiochimBiophys Acta Rev Cancer, 1874(1):188390. *Contributed equally.

3. Jingyu Shao*, Beibei Han*, Pengxiu Cao*,Bingwei Zhang, Ming Liu, Danyu Li, Nan Zhou, Qiang Hao, Xianglin Duan, YanzhongChang, Akira Nakai, Yumei Fan, Ke Tan. (2019) HSF1 phosphorylation bycyclosporin A confers hyperthermia sensitivity through suppression of HSPexpression. Biochim Biophys Acta Gene Regul Mech, 1862(8):846-857. *Contributedequally.

4. Chen Shenghan, CaoPengxiu, Dong Ningzheng, Peng Jianhao, Zhang Chunyi, Wang Hao, Zhou Tiantian,Yang Junhua, Zhang Yue, Martelli Elizabeth E., Prasad Sathyamangla V. Naga,Miller Rachel E., Malfait Anne-Marie, Zhou Yiqing, Wu Qingyu. (2015)PCSK6-mediated corin activation is essential for normal blood pressure. NatureMedicine, 21(9):1048-1053.

5. Junhua Miao, Mutao Xu, Yuhuan Kuang,Shuhong Pan, Jianyuan Hou, Pengxiu Cao, Xianglin Duan, Yanzhong Chang, HabelhahHasem, Nan Zhou, Ke Tan, Yumei Fan. (2020) Deferasirox protects againsthydrogen peroxide-induced cell apoptosis by inhibiting ubiquitination anddegradation of p21WAF1/CIP1. Biochem Biophys Res Commun. 524(3):736-743.

6. Cao Pengxiu*, Sun Wenyu*, Kramp Kristopher,Zheng Maohua, Salom David, Jastrzebska Beata, Jin Hui, Palczewski Krzysztof,Feng Zhaoyang. (2012) Light-sensitive coupling of rhodopsin and melanopsin toGi/o and Gq signal transduction in Caenorhabditis elegans. FASEB J.,26(2):480-491. *Contributed equally.

7. Salom David*, Cao Pengxiu*, Sun Wenyu*,Kramp Kristopher, Jastrzebska Beata, Jin Hui, Feng Zhaoyang, PalczewskiKrzysztof. (2012) Heterologous expression of functional G-protein-coupledreceptors in Caenorhabditis. FASEB J., 26(2):492-502. *Contributed equally.

8. Cao Pengxiu*, Yuan Yiyuan*, Pehek ElizabethA., Moise Alex R., Huang Ying, Palczewski Krzysztof, Feng Zhaoyang. (2010)Alpha-synuclein disrupted dopamine homeostasis leads to dopaminergic neurondegeneration in Caenorhabditis elegans. PLoS ONE, 5 (2), e9312. *Contributedequally.

9. Cao Pengxiu, Song Jian, Zhou Chunjiang,Weng Manli, Liu Jing, Wang Fuxin, Zhao Feng, Feng Dianqi, Wang Bin. (2009)Characterization of multiple cold induced genes from Ammopiptanthus mongolicusand functional analyses of gene AmEBP1. Plant Molecular Biology, 69(5),529-539.

10. Fei Y.B.*, Cao P.X.*, Gao S.Q., Wang B.,Wei L.B.,Zhao J., Chen G.& Wang B.H. (2008) Purification and analysis ofantifreeze proteins from a ligneous plant. Preparative Biochemistry andBiotechnology, 38(2), 172-183. *Contributed equally.

11. Fei Y.B.*, Cao P.X.*, Gao S.Q., Wei L.B.&Wang B. (2005) Discovery of a homolog of siderophilin in a plant. Journalof Integrative Plant Biology, 47 (12), 1409-1411. *Contributed equally.

12. Chen Yuanyuan, Jastrzebska Beata, CaoPengxiu, Zhang Jianye, Wang Benlian, Sun Wenyu, Yuan Yiyuan, Feng Zhaoyang,Palczewski Krzysztof. (2014) Inherent instability of the retinitis pigmentosaP23H mutant opsin. The Journal of Biological Chemistry, 289(13):9288-9303.

13. Yuan Yiyuan, Hakimi Parvin, Kao Clara, KaoAllison, Liu Ruifu, Janocha Allison, Boyd-Tressler Andrea, Hang Xi, AlhoraibiHanna, Slater Erin, Xia Kevin, Cao Pengxiu, Shue Quinn, Ching Tsui-Ting, HsuAo-Lin, Erzurum Serpil C., Dubyak George R., Berger Nathan A., Hanson RichardW., Feng Zhaoyang. (2016) Reciprocal changes in phosphoenolpyruvatecarboxykinase and pyruvate kinase with age are a determinant of aging inCaenorhabditis elegans. The Journal of Biological Chemistry, 291(3):1307-1319.

14. Yuan Yiyuan, Cao Pengxiu, Smith Mark A.,Kramp Kristopher, Huang Ying, Hisamoto Naoki, Matsumoto Kunihiro, HatzoglouMaria, Jin Hui, Feng Zhaoyang. (2011) Dysregulated LRRK2/p38 signaling inresponse to endoplasmic reticulum stress leads to dopaminergic neurondegeneration. PLoS ONE, 6 (8):e22354.

15. Salom David, Cao Pengxiu, Yuan Yiyuan,Miyagi Masaru, Feng Zhaoyang, Palczewski Krzysztof. (2015) Isotopic labeling ofmammalian GPCRs heterologously expressed in Caenorhabditis elegans. Accepted inAnal Biochem., 2015,472:30-36.

16. Zheng Maohua, Cao Pengxiu, Yang Jiong, XuX. Z. Shawn, Feng Zhaoyang. (2012) Calcium imaging of multiple neurons infreely behaving C. elegans. Journal of Neuroscience Methods. 206 (1), 78–82.

17. Jastrzebska Beata, Salom David, Jin Hui,Cao Pengxiu, Sun Wenyu, Palczewski Krzysztof, Feng Zhaoyang. (2013) Expressionof mammalian G protein-coupled receptors in Caenorhabditis elegans. Methods inEnzymology.520:239-256.

18. Zhou Chunjiang, Chen Cuixia, Cao Pengxiu,Wu Suowei, Sun Jianwei, Jin Demin, Wang Bin. (2007). Characterization and finemapping of RppQ, a resistance gene to southern corn rust in maize. MolecularGenetics and Genomics, 278 (6), 723-728.

19. Song Jian, Liu Jing, Weng Manli, HuangYanyan, Luo Lei, Cao Pengxiu, Sun Haiwei, Liu Jie, Zhao Jinhong, Feng Dianqi,Wang Bin. (2013) Cloning of galactinol synthase gene from AmmopiptanthusMongolicus and its expression in transgenic Photinia serrulate plants. Gene.15, 513(1):118-127.

20. Liang F., Kong F., Zhou C., Cao P., Ye C.& Wang B. (2005) Cloning and characterization of a non-TIR-NBS-LRR typedisease resistance gene analogue from peach. DNA Sequence, 16 (2), 103-110.

21. Bai L., Ye C., Lu J., Yang D., Xue H., PanY., CaoP., Wang B., & Liu M. (2009) Ipt gene transformation in petunia byan Agrobacterium mediated method. Journal of Immunoassay and Immunochemistry,30(2):224-231.