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尤琳浩

发布时间：2019-04-22

尤琳浩 博士

副教授 硕士生导师

港澳宝80801“精英计划”引进人才

联系方式：[email protected]；18533127036

所属专业、方向：生理学专业、神经生理学方向

学习和工作经历

2005.09-2009.06 河北农业大学生物技术专业，获得理学学士学位

2009.09-2015.06 港澳宝80801硕博连读，获理学博士学位 导师：常彦忠教授

2015.09-2018.07 国家纳米科学中心博士后，合作导师：聂广军研究员

2018.07-至今 港澳宝80801，解剖生理学教研室，专任教师

主要教学科研工作：

教学方面：承担本科生课程包括《组织学与解剖学》、《组织学与解剖学实验》、《人体及动物生理学实验》、《铁与人类健康》等。

科研方面：（1）脑铁代谢及稳态调节的研究；（2）脑铁代谢与神经退行性疾病发病机制的研究；（3）采用纳米技术携带药物治疗脑铁失衡疾病的研究；（4）脑铁代谢在情绪相关疾病中的作用

代表论文：

Xin Zheng#, Likun Wang#, Linhao You*, Yong‐Xin Liu, Michael Cohen, Siyu Tian, Wenjun Li, Xiaofang Li*. Dietary licorice enhances in vivo cadmium detoxification and modulates gut microbial metabolism in mice. iMeta, 2022, e7.

Lin-hao You#, Jing Wang#, Tian-qing Liu#, Yin-long Zhang, Xue-xiang Han, Ting Wang, Shan-shan Guo, Tian-yu Dong, Jun-chao Xu, Gregory J Anderson, Qiang Liu, Yan-Zhong Chang*, Xin Lou*, Guang-jun Nie*. Targeted Brain Delivery of Rabies Virus Glycoprotein 29-Modified Deferoxamine-Loaded Nanoparticles Reverses Functional Deficits in Parkinsonian Mice. ACS nano 2018, 12(5): 4123-4139. IF: 13.942

Linhao You#, Caizhen Yan#, Bingjie Zheng, Yunzhe Ci, Shiyang Chang, Peng Yu, Guofen Gao, Haiyan Li, Tianyu Dong, Yanzhong Chang*, Astrocyte hepcidin is a key factor in LPS-induced neuronal apoptosis. Cell death & disease 2017, 8(3): e2676. IF: 5.965

Linhao You, Fei Li, Lan Wang, Shue Zhao, Shumin Wang, Lili Zhang, Lihong Zhang, Xianglin Duan, Peng Yu*, Yanzhong Chang*, Brain iron accumulation exacerbates the pathogenesis of MPTP-induced Parkinson's disease, Neuroscience, 2015. 284: 234-246. IF: 3.327

Linhao You#, Zhen Li#, Xianglin Duan, Baolu Zhao, Yanzhong Chang*, Zhenhua Shi*, Mitochondrial ferritin suppresses MPTP-induced cell damage by regulating iron metabolism and attenuating oxidative stress, Brain Research, 2016. 1642: 33-42.

尤琳浩#, 郑鑫, 常彦忠*. 脑铁代谢及调控. 生命科学 2012, 24(8): 731-741. CSCD 中文核心 (2012年8月)

Yong Xu, Yating Zhang, Jian-Hua Zhang, Kang Han, Xinwei Zhang, Xue Bai, Lin-Hao You, Peng Yu, Zhenhua Shi, Yan-Zhong Chang*, Guofen Gao*. Astrocyte hepcidin ameliorates neuronal loss through attenuating brain iron deposition and oxidative stress in APP/PS1 mice. Free Radical Biology and Medicine. 2020, 158: 84-95

Xinwei Zhang, Yu-Jing Gou, Yating Zhang, Jie Li, Kang Han, Yong Xu, Haiyan Li, Lin-Hao You, Peng Yu, Yan-Zhong Chang*, Guofen Gao*. Hepcidin overexpression in astrocytes alters brain iron metabolism and protects against amyloid-β induced brain damage in mice. Cell Death Discovery. 2020, 6: 113

Yun-Zhe Ci#, Haiyan Li#, Lin-Hao You, Yu Jin, Rui Zhou, Guofen Gao, Maggie Pui Man Hoi, Chunyan Wang, Yan-Zhong Chang*, Peng Yu*. Iron overload induced by IRP2 gene knockout aggravates symptoms of Parkinson's disease. Neurochem Int. 2020, 134: 104657.

Lan Wang#, Xiaopeng Liu#, Lin-Hao You, Yun-Zhe Ci, Shiyang Chang, Peng Yu, Guofen Gao*, Yan-Zhong Chang*. Hepcidin and iron regulatory proteins coordinately regulate ferroportin 1 expression in the brain of mice. J Cell Physiol. 2019, 234(5):7600-7607.

Yinlong Zhang, JingYan Wei*, Jiaqi Xu, Wei Sun Leong, Guangna Liu, Tianjiao Ji, Zhiqiang Cheng, Jing Wang, Jiayan Lang, Ying Zhao, Linhao You, Xiao Zhao, Taotao Wei, Greg J Anderson, Sheng Qi, Jing Kong, Guangjun Nie*, Suping Li*, Suppression of tumor energy supply by liposomal nanoparticle-mediated inhibition of aerobic glycolysis, ACS Appl. Mater. Interfaces, 2018, 10 (3), 2347–2353

Zi Xu#, Weijia Sun#, Yuheng Li#, Shukuan Ling, Chenyang Zhao, Guohui Zhong, Dingsheng Zhao, Jinping Song, Hailin Song, Jinqiao Li, LinhaoYou, Guangjun Nie, Yanzhong Chang*, Yingxian Li*, The regulation of iron metabolism by hepcidin contributes to unloading-induced bone loss. Bone 2017, 94: 152-161.

Ya-Shuo Zhao#, Li-Hong Zhang#, Pan-Pan Yu, Yu-Jing Gou, Jing Zhao, Lin-Hao You, Zhan-You Wang, Xin Zheng, Liang-Jun Yan, Peng Yu*, Yan-Zhong Chang*, Ceruloplasmin, a potential therapeutic agent for Alzheimer's disease. Antioxidants & Redox Signaling 2017.

Zhenhua Shi#, Fangfang Shi#, Yueqi Wang, Alex D. Sheftel, Guangjun Nie, Yashuo Zhao, Linhao You, Yujing Gou, Xianglin Duan, Baolu Zhao, Hongmeng Xu, Chunyan Li, Yanzhong Chang*, Mitochondrial ferritin, a new target for inhibiting neuronal tumor cell proliferation, Cell Mol Life Sci, 2015, 72(5): 983-997

Yumei Fan#, Jie Zhang#, Linlin Cai#, Shengnan Wang, Caizhi Liu, Yongze Zhang, Linhao You, Yujian Fu, Zhenhua Shi, Zhimin Yin, Lan Luo, Yanzhong Chang*, Xianglin Duan* The effect of anti-inflammatory properties of ferritin light chain on lipopolysaccharide-induced inflammatory response in murine macrophages, Biochim Biophys Acta, 2014, 1843(11): 2775-2783

项目：

1、国家自然科学基金（31900739）：小胶质细胞敲除FPN1影响帕金森氏症病程的机制研究； 2020.01-2022.12；主持；24万

2、港澳宝80801博士基金（L2019B21）：脑铁缺乏对认知、运动能力影响的机制研究；2019.01-2021.12；主持；30万

3、中国博士后科学基金面上资助（2020M670687）：星形胶质细胞Ferroportin1影响老年小鼠认知功能的机制研究；2019-2021；主持；8万

4、国家自然科学基金（31900739）：星形胶质细胞铜蓝蛋白对多巴胺能神经元铁代谢调控机制的研究；2020.01-2022.12；第二参与人；59万。

5、河北省重点项目（E2021205003）：祛铁靶向纳米材料设计及对缺血性脑卒中神经损伤保护作用及其机制研究；2021.01-2023.12，参与，100万元。

教学：

1、港澳宝80801和悉尼科技大学联合办学的教师培训，并取得资格证书

2、“铁与人类健康”课程的国际化教学模式改革与实践获得2019年河北省教学成果二等奖

3、“铁与人类健康”课程获得港澳宝80801第十一届高等教育教学成果奖一等奖

4、2019年“铁与人类健康”课程获得校级线下一流课程称号。

其他：

1、参与2021年在高等教育出版社出版的《组织学与解剖学数字课程》的编写。

2、参与2017年在Royal Society of Chemistry出版的《Oxidative Stress and Redox Signaling in Parkinson’s Disease》中一个章节的编写。

3、参与2012年人民卫生出版社出版的《铁代谢失衡疾病的分子生物学原理》一书中多个章节的编写。